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Page 1
Heat stress activates YAP/TAZ to induce the heat shock transcriptome.
Luo M, Meng Z, Moroishi T, Lin KC, Shen G, Mo F, Shao B, Wei X, Zhang P, Wei Y, Guan KL. Luo M, et al. Nat Cell Biol. 2020 Dec;22(12):1447-1459. doi: 10.1038/s41556-020-00602-9. Epub 2020 Nov 16. Nat Cell Biol. 2020. PMID: 33199845 Free PMC article.
The Hippo pathway plays critical roles in cell growth, differentiation, organ development and tissue homeostasis, whereas its dysregulation can lead to tumorigenesis. ...
The Hippo pathway plays critical roles in cell growth, differentiation, organ development and tissue homeostasis, whereas its dysregu …
Regulation of posterior body and epidermal morphogenesis in zebrafish by localized Yap1 and Wwtr1.
Kimelman D, Smith NL, Lai JKH, Stainier DY. Kimelman D, et al. Elife. 2017 Dec 28;6:e31065. doi: 10.7554/eLife.31065. Elife. 2017. PMID: 29283341 Free PMC article.
We further find that Yap1 and Wwtr1, also via Fibronectin, have an essential role in the epidermal morphogenesis necessary to form the initial dorsal and ventral fins, a process previously thought to involve bending of an epithelial sheet, but which we now show involves co …
We further find that Yap1 and Wwtr1, also via Fibronectin, have an essential role in the epidermal morphogenesis necessary to form th …
Prevalence of the Hippo Effectors YAP1/TAZ in Tumors of Soft Tissue and Bone.
Isfort I, Elges S, Cyra M, Berthold R, Renner M, Mechtersheimer G, Åman P, Larsson O, Ratner N, Hafner S, Simmet T, Schliemann C, Rossig C, Dirksen U, Grünewald I, Wardelmann E, Huss S, Hartmann W, Trautmann M. Isfort I, et al. Sci Rep. 2019 Dec 23;9(1):19704. doi: 10.1038/s41598-019-56247-8. Sci Rep. 2019. PMID: 31873172 Free PMC article.
Tumors of soft tissue and bone represent a heterogeneous group of neoplasias characterized by a wide variety of genetic aberrations. ...Our findings identify nuclear YAP1 and TAZ positivity as a common feature in subsets of sarcomas of soft tissue and bone and provi …
Tumors of soft tissue and bone represent a heterogeneous group of neoplasias characterized by a wide variety of genetic aberrations. …
Stem cell regulation by the Hippo pathway.
Hiemer SE, Varelas X. Hiemer SE, et al. Biochim Biophys Acta. 2013 Feb;1830(2):2323-34. doi: 10.1016/j.bbagen.2012.07.005. Epub 2012 Jul 20. Biochim Biophys Acta. 2013. PMID: 22824335 Review.
In vivo studies have implicated YAP as a key regulator of tissue-specific progenitor cell proliferation and tissue regeneration. Misappropriate activation of nuclear TAZ and YAP transcriptional activity drives tissue overgrowth and is implicated in cancer ste …
In vivo studies have implicated YAP as a key regulator of tissue-specific progenitor cell proliferation and tissue regeneratio …
Strong as a Hippo's Heart: Biomechanical Hippo Signaling During Zebrafish Cardiac Development.
Bornhorst D, Abdelilah-Seyfried S. Bornhorst D, et al. Front Cell Dev Biol. 2021 Aug 5;9:731101. doi: 10.3389/fcell.2021.731101. eCollection 2021. Front Cell Dev Biol. 2021. PMID: 34422841 Free PMC article. Review.
The heart is comprised of multiple tissues that contribute to its physiological functions. During development, the growth of myocardium and endocardium is coupled and morphogenetic processes within these separate tissue layers are integrated. ...Evidently, Hippo pat …
The heart is comprised of multiple tissues that contribute to its physiological functions. During development, the growth of myocardi …
Identification of BRCC3 and BRCA1 as Regulators of TAZ Stability and Activity.
Sberna S, Lopez-Hernandez A, Biancotto C, Motta L, Andronache A, Verhoef LGGC, Caganova M, Campaner S. Sberna S, et al. Cells. 2023 Oct 11;12(20):2431. doi: 10.3390/cells12202431. Cells. 2023. PMID: 37887275 Free PMC article.
TAZ (WWTR1) is a transcriptional co-activator regulated by Hippo signaling, mechano-transduction, and G-protein couple receptors. Once activated, TAZ and its paralogue, YAP1, regulate gene expression programs promoting cell proliferation, survival, and differentiation, thu …
TAZ (WWTR1) is a transcriptional co-activator regulated by Hippo signaling, mechano-transduction, and G-protein couple receptors. Onc …
The novel role of Hippo-YAP/TAZ in immunity at the mammalian maternal-fetal interface: Opportunities, challenges.
Huang Z, Zhou J, Leung WT, Gober HJ, Pan X, Li C, Li L, Wang L. Huang Z, et al. Biomed Pharmacother. 2020 Jun;126:110061. doi: 10.1016/j.biopha.2020.110061. Epub 2020 Mar 4. Biomed Pharmacother. 2020. PMID: 32145593 Free article. Review.
The Hippo-Yes-associated protein (YAP)/transcriptional co-activator with PDZ-binding motif (TAZ), originally identified as a regulator of tissue generation and tumorigenesis, has been proven to have a pivotal position in immunity. ...
The Hippo-Yes-associated protein (YAP)/transcriptional co-activator with PDZ-binding motif (TAZ), originally identified as a regulator of …
The Hippo effector TAZ (WWTR1) transforms myoblasts and TAZ abundance is associated with reduced survival in embryonal rhabdomyosarcoma.
Mohamed A, Sun C, De Mello V, Selfe J, Missiaglia E, Shipley J, Murray GI, Zammit PS, Wackerhage H. Mohamed A, et al. J Pathol. 2016 Sep;240(1):3-14. doi: 10.1002/path.4745. J Pathol. 2016. PMID: 27184927 Free PMC article.
The Hippo effector YAP has recently been identified as a potent driver of embryonal rhabdomyosarcoma (ERMS). Most reports suggest that the YAP paralogue TAZ (gene symbol WWTR1) functions as YAP but, in skeletal muscle, TAZ has been reported to promote myogenic diffe …
The Hippo effector YAP has recently been identified as a potent driver of embryonal rhabdomyosarcoma (ERMS). Most reports suggest tha …
Rho Signaling-Directed YAP/TAZ Regulation Encourages 3D Spheroid Colony Formation and Boosts Plasticity of Parthenogenetic Stem Cells.
Pennarossa G, Paffoni A, Ragni G, Gandolfi F, Brevini TAL. Pennarossa G, et al. Adv Exp Med Biol. 2020;1237:49-60. doi: 10.1007/5584_2019_423. Adv Exp Med Biol. 2020. PMID: 31376140 Review.
Cell proliferation, apoptosis and differentiation are essential processes from the early phases of embryogenesis to adult tissue formation and maintenance. These mechanisms also play a key role in embryonic stem cells (ESCs) that are able to proliferate maintaining …
Cell proliferation, apoptosis and differentiation are essential processes from the early phases of embryogenesis to adult tissue form …
Mechanical strain regulates the Hippo pathway in Drosophila.
Fletcher GC, Diaz-de-la-Loza MD, Borreguero-Muñoz N, Holder M, Aguilar-Aragon M, Thompson BJ. Fletcher GC, et al. Development. 2018 Mar 8;145(5):dev159467. doi: 10.1242/dev.159467. Development. 2018. PMID: 29440303 Free PMC article.
Animal cells are thought to sense mechanical forces via the transcriptional co-activators YAP (or YAP1) and TAZ (or WWTR1), the sole Drosophila homolog of which is named Yorkie (Yki). ...Finally, our results in follicle cells appear generally applicable to other tissues …
Animal cells are thought to sense mechanical forces via the transcriptional co-activators YAP (or YAP1) and TAZ (or WWTR1), the sole …
27 results